In the fall of 1997, the College dedicated the expanded and renovated building as the Robert N. Noyce '49 Science Center, in honor of the alumnus whose invention, the integrated circuit, sparked the information age. 2008 marked the the completion of an extensive round of renovations.

The facility includes refurbished teaching and research laboratories, classroom and office space, a science library, a computer laboratory, and several study areas. The addition connects two of the wings with a courtyard in between.

The building houses the departments of biology, chemistry, mathematics and computer science, physics, and psychology. Containing modern scientific equipment and instrumentation, the facility has laboratories, classrooms, and seminar rooms, which are equipped with electronic and other modern instructional tools. The building also houses the Kistle Science Library and the Physics Historical Museum. In the northeast section of the building, a greenhouse is used as an instructional and research facility.